Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder in Patients With a Characterized Depressive Episode in Primary Care

Publication date: Jun 12, 2025

The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying bipolar disorder among adult patients presenting with a current major depressive episode in primary care. The study will compare the results of the medical device diagnostic test to those of standardized psychiatric clinical evaluation, to evaluate its sensitivity, specificity, and overall clinical utility. The main research questions are : * Can the investigational medical device accurately distinguish bipolar disorder from unipolar depression ? * How does its diagnostic accuracy compare with validated psychiatric questionnaires commonly used in clinical practice ? Participants will : * Provide a blood sample for biomarker analysis using the investigational diagnostic device. * Complete a few validated psychiatric assessment tools (e. g., MDQ, MINI). * Share sociodemographic and clinical data relevant to psychiatric evaluation.

Concepts Keywords
Addictive bipolar disorder
Biologiques blood biomarker-based algorithm
Diabetes blood biomarkers
Psychiatry composite diagnostic tool
composite medical device
diagnosis
major depressive episode
mood depression questionnaire
primary care

Semantics

Type Source Name
disease MESH Bipolar Disorder
disease MESH Mood Disorder
disease MESH unipolar depression
disease MESH schizophrenia
drug DRUGBANK Fluoxetine
drug DRUGBANK Aripiprazole
drug DRUGBANK Hydroxyzine
disease MESH autoimmune disease
disease MESH Crohn’s disease
disease MESH thyroiditis
drug DRUGBANK Methylenedioxyethamphetamine
disease MESH Depression

Original Article

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