Publication date: Jun 24, 2025
We describe the kinetics of maternally derived antibodies in infants in the first 6 months of life following 2- or 3-dose maternal vaccination during pregnancy or postpartum. This prospective, multicenter cohort study enrolled infants born to mothers vaccinated with 2- (n = 280) or 3-dose (boosted) monovalent messenger RNA vaccines in pregnancy (n = 202) or to mothers vaccinated postpartum (n = 36) from July 2021 to January 2022. Binding (immunoglobulin G to S and receptor-binding domain), pseudovirus, and live neutralizing antibody (nAb) geometric mean titers (GMTs) to vaccine and Omicron BA. 1/BA. 5 strains were measured at birth and 2 and 6 months of age. Antibody half-life and the effect of maternal or infant COVID-19 infection were assessed. Significantly higher GMTs of binding antibody and nAb to all antigens were present at birth and 2 months in infants of boosted mothers (P
| Concepts | Keywords |
|---|---|
| Immunoglobulin | Antibodies |
| July | Antibody |
| Live | Binding |
| Pregnancy | Boosted |
| Covid | |
| Dose | |
| Infant | |
| Infants | |
| Maternal | |
| Mothers | |
| Nab | |
| Postpartum | |
| Pregnancy | |
| Vaccinated | |
| Vaccination |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | infection |