SARS-CoV-2 infection increases long-term risk of pneumonia in an urban population: an observational cohort study up to 46 months post-infection.

Publication date: Jun 25, 2025

COVID-19 could increase susceptibility to future pulmonary infections. Given the sheer number of individuals infected by SARS-CoV-2, increased prevalence of future pulmonary infections could be a public health concern. We conducted a retrospective study to determine whether COVID-19 is associated with increased incidence of future pneumonia. In an urban population in Montefiore Health System in the Bronx between 03/1/2020 and 01/31/2024, there were 64,376 patients with a prior history of COVID-19, 1. 2 million patients without (controls), and 8468 patients with influenza without COVID-19. Controls were propensity-matched. Multivariate Cox adjusted hazard ratios (aHR) with 95% confidence interval (CI) accounting for confounders were calculated. Outcomes were also analyzed with respect to comorbidities, median incomes, insurance status, and unmet social needs. Hospitalized COVID-19 (aHR=3. 69, 95%CI[3. 29,4. 15]) and non-hospitalized COVID-19 (aHR=1. 40[1. 27,1. 55]) patients had higher risk of developing future pneumonia compared to controls. Hospitalized COVID-19 patients experienced more recurrent pneumonia episodes (2. 3 cases/patient, p

Concepts Keywords
Accounting asthma
Bronx chest computed tomography
Increased health disparity
Pneumonia

Semantics

Type Source Name
disease MESH SARS-CoV-2 infection
pathway REACTOME SARS-CoV-2 Infection
disease MESH pneumonia
disease MESH infection
disease IDO susceptibility
disease IDO history
disease MESH influenza
disease MESH Long Covid
disease MESH asthma
pathway KEGG Asthma
disease MESH health disparity

Original Article

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