Sound of Success: Intestinal Ultrasound in the Management of Refractory Stricturing Crohn’s Disease.

Publication date: Jun 25, 2025

We present a case of a female with complex pediatric-onset stricturing small bowel and colonic Crohn’s disease. She was refractory to multiple advanced therapies, requiring dual therapy with risankizumab and upadacitinib to induce healing. Using intestinal ultrasound to monitor her response to therapy, we ultimately de-escalated to risankizumab monotherapy due to a reduction of inflammatory burden. We present this case to highlight the use and importance of intestinal ultrasound to guide changes in therapy, discussing its use in practice for patients with inflammatory bowel disease.

Concepts Keywords
Disease Drug-induced amenorrhea
Guide Drug-induced lupus
Intestinal Inflammatory bowel disease
Therapy Infliximab
Ultrasound Intestinal wall thickness
Magnetic resonance enterography
Risankizumab
Upadacitinib

Semantics

Type Source Name
drug DRUGBANK Spinosad
disease MESH Crohn’s Disease
disease MESH inflammatory bowel disease
pathway KEGG Inflammatory bowel disease
disease MESH amenorrhea
drug DRUGBANK Infliximab

Original Article

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