Publication date: Jun 27, 2025
In brain scans of human carriers of the 22q11. 2 deletion, connectivity patterns also evolved across puberty. The human data didnt cover every critical point of brain development, making it harder to pinpoint precisely when connectivity shifts occur. In childhood, certain brain areas were too connected, while in adolescence and early adulthood, connectivity weakened. By adulthood, spine density had decreased sharply, aligning with the drop in connectivity seen in the brain scans. In LgDel mice, this enzyme was overactive and linked to abnormal spine densities and brain connectivity. At a younger, prepubertal age, the mouse brains showed widespread hyperconnectivity too many connections between brain regions. Individuals with this syndrome can experience heart defects, learning disabilities, and delays in speech and motor skills, as well as an increased risk for conditions like autism and schizophrenia.
| Concepts | Keywords |
|---|---|
| Autism | Autism |
| Carrie | Brain |
| Culprit | Called |
| Neuroscience | Condition |
| Connections | |
| Connectivity | |
| Deletion | |
| Genetic | |
| Gozzi | |
| Molecular | |
| Puberty | |
| Risk | |
| Schizophrenia | |
| Shift | |
| Syndrome |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Tropicamide |
| disease | MESH | Alexia |
| disease | MESH | psychiatric disorders |
| disease | MESH | syndrome |
| disease | MESH | defects |
| disease | MESH | learning disabilities |
| disease | MESH | causes |
| disease | MESH | autism |
| disease | MESH | 22q11.2 deletion syndrome |
| disease | MESH | schizophrenia |