Publication date: Jun 26, 2025
This study investigated the relationship between motor subtypes of Parkinson’s disease (PD) and plasma uric acid (UA) levels, as well as the neutrophil-to-lymphocyte ratio (NLR), to explore potential biomarkers. Seventy-three PD patients admitted between January 2021 to December 2023 were categorized into tremor-dominant (TD) and non-tremor-dominant (NTD) groups based on their motor subtypes. General patient characteristics, blood uric acid (UA) levels, neutrophil-to-lymphocyte ratio (NLR), and inflammatory markers tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were compared. Spearman’s analysis explored the relationships between motor subtypes, UA, NLR, and inflammatory markers. No significant differences were found between groups in age, sex, disease duration, levodopa equivalent daily dose (LEDD), education, Mini-Mental State Examination (MMSE), or rapid eye movement sleep behavior disorder (RBD) prevalence (p > 0. 05). The NTD group showed higher Hoehn-Yahr (H-Y) stage, non-tremor scores, Unified Parkinson’s Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and prevalence of freezing of gait, while the TD group had higher tremor scores (p
| Concepts | Keywords |
|---|---|
| Biomarkers | Motor subtypes |
| December | Neutrophil-to-Lymphocyte ratio |
| Parkinson | Parkinson’s disease |
| Sex | Uric acid |
| Td |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Parkinson’s disease |
| drug | DRUGBANK | Uric Acid |
| disease | MESH | tremor |
| drug | DRUGBANK | Levodopa |
| disease | MESH | rapid eye movement sleep behavior disorder |
| disease | MESH | Depression |
| disease | MESH | Anxiety |
| disease | MESH | gait |