Publication date: Jun 01, 2025
The underlying mechanisms of long-term sequelae of the COVID-19 infection, including fatigue, memory issues, and attention deficit, remain to be understood. Therefore, we investigated the Diffusion MRI scans of 73 COVID-Recovered Patients (CRPs) and 46 Healthy Controls (HCs) using Fixel-based analysis to study the sub-voxel microstructural properties of nervous tissue. We compared the Fiber Density (FD), log scaled Fiber Cross-section (log-FC), and a combined fiber density and cross-section measure (FDC) across the cohorts. Our study reveals significant alterations (pFWE HC), perigenual corpus callosum (FD; CRP > HC), fornix (log-FC, FDC; CRP > HC), right arcuate fasciculus (FD; CRP
Open Access PDF
| Concepts | Keywords |
|---|---|
| Fatigue | COVID-19 |
| Healthy | dMRI |
| Mri | Fiber cross-section |
| Sequelae | Fiber density |
| Voxel |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | sequelae |
| disease | MESH | infection |
Original Article
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