Improvement of Fatigue and Body Composition in Women with Long COVID After Non-Aerobic Therapeutic Exercise Program.

Publication date: May 26, 2025

Background/Objective: Fatigue is one of the most recurrent and most disabling symptoms of long COVID (LC) and is associated with a worse quality of life. Reducing body fat in these patients could be important to mitigate fatigue and post-exertional worsening. Aerobic exercise may not be indicated in LC patients who have orthostatic tachycardia and post-exertional worsening. The aim of this study was to evaluate the effects of a personalized supine therapeutic motor control exercise program on fatigue and fat tissue in women with LC. Methods: A single-arm exploratory case study, with a pre-post format, was conducted on 17 women with LC to test the effects of a plank-based strengthening exercise program on fatigue, which was evaluated by the Modified Fatigue Impact Scale and fat tissue assessed by bioimpedance. The twelve-week program included two weekly sessions. The exercise program was personalized, considering the symptoms and characteristics of the patients. Results: Participants with overweight or obesity (n = 12) comprised 70% of the entire sample. After completing the exercise program this value decreased by 5. 9 percentage points. Significant differences were found in the total [(MD  = -1. 72, 95% CI -2. 57 to -0. 86), r = 0. 73], trunk, upper and inner limbs body fat percentages (p < 0. 05). The overall fatigue decreased at 12 weeks [(MD  =  -14. 00, 95% CI -21. 69 to -6. 31), r = 0. 69] as well as the physical and psychosocial fatigue sub-scale (p  <  0. 001); no differences were observed in the cognitive sub-scale. Conclusions: The plank-based personalized strengthening exercise program showed rapid improvements in fatigue and fat percentages. It could be an effective strategy to achieve improvements for LC patients.

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Concepts Keywords
Bioimpedance body fat distribution
Covid exercise therapy
Obesity fatigue
Weekly post-acute COVID-19 syndrome
Women

Semantics

Type Source Name
disease MESH Long COVID
disease IDO quality
disease MESH tachycardia
disease MESH overweight
disease MESH obesity
drug DRUGBANK L-Valine
drug DRUGBANK Coenzyme M
disease MESH body fat distribution
disease MESH dyspnea
disease MESH abnormalities
disease MESH cognitive impairment
disease MESH post traumatic stress disorder
disease MESH COVID 19
disease MESH infection
disease MESH etiology
disease IDO immune response
disease MESH inflammation
disease MESH mitochondrial dysfunction
disease MESH autoimmune diseases
disease MESH depression
disease MESH syndrome
disease IDO acute infection
disease MESH stroke
disease MESH hyperventilation
pathway REACTOME Metabolism
pathway KEGG Oxidative phosphorylation
disease MESH critical illness
disease MESH death
disease MESH Abdominal obesity
drug DRUGBANK Methionine
disease MESH heart disease
disease MESH abdominal hernia
disease MESH pregnancy history
disease IDO intervention
drug DRUGBANK BIA
drug DRUGBANK Trestolone
drug DRUGBANK Isoxaflutole
disease MESH posture
disease MESH Underweight
disease IDO symptom
disease MESH symptom exacerbation
drug DRUGBANK Nonoxynol-9
disease MESH mental fog
drug DRUGBANK Tilmicosin
disease MESH sedentary lifestyle
disease MESH oxidative stress
disease IDO production
disease MESH postural orthostatic tachycardia syndrome
disease MESH myalgic encephalomyelitis
drug DRUGBANK Oxygen
disease MESH orthostatic intolerance
disease MESH muscular fatigue
disease MESH anxiety
disease MESH sequelae
drug DRUGBANK Dimercaprol
disease MESH Sleep Quality
disease MESH Viral Infections
disease MESH Sarcopenia
disease MESH Myocarditis
disease MESH Multiple Sclerosis
disease MESH Brain Disease
disease MESH Fibromyalgia
disease MESH Affective Symptoms

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