Moles can become melanomas through nongenetic transitions, UC Irvine study shows

Publication date: Jun 27, 2025

A research powerhouse, the cancer center brings together basic and translational scientists with clinician investigators to drive discoveries through the pipeline into the clinical arena. Called melanocytes, these cells can form a pigmented lesion on the skin called a mole and also known as a nevus. While the BRAF mutation induced rare melanomas in albino mice, it induced only normal moles in black mice. Ganesan serves as co-director for Biotechnology, Imaging and Drug Development and co-director for Molecular Diagnostics and Therapeutics at the UCI Health Chao Family Comprehensive Cancer Center. The center also offers more than 500 clinical trials, including the regions largest portfolio of early-phase and investigator-initiated trials. His goal is to develop new therapies to treat melanoma and pigmentary disorders. It is also one of the few U. S. programs to provide transplants for debilitating autoimmune diseases such as multiple sclerosis.

Concepts Keywords
Arthritis Center
Biotechnology County
Instagram Ganesan
July Irvine
Melanoma
Melanomas
Mutation
Mutations
Normal
Orange
Phd
Prevent
Skin
Tumors
Uci

Semantics

Type Source Name
disease MESH critically ill
disease MESH autoimmune diseases
disease MESH multiple sclerosis
drug DRUGBANK Huperzine B
drug DRUGBANK Gold
disease MESH emergency
disease MESH vitiligo
disease MESH Skin Diseases
disease MESH Arthritis
pathway REACTOME Developmental Biology
drug DRUGBANK Tropicamide
disease MESH nevus
drug DRUGBANK Nonoxynol-9
pathway KEGG Melanoma
disease MESH skin cancer
disease MESH cancer
disease MESH melanomas

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