Publication date: Jul 01, 2025
Gait disturbances causing impaired mobility are common in Parkinson’s disease after bilateral deep brain stimulation of the subthalamic nucleus. We describe subthalamic subregions where neurostimulation had a positive effect on gait or provoked gait disturbances. 98 patients were classified according to changes in MDS-UPDRS III gait items: gait improvement (≥1-point improvement in items 3. 10 and/or 3. 11), gait deterioration (≥1-point worsening, confirmed by repeated clinical documentation), or no change. We performed a segregation analysis for (1) and (3) by simulating volumes of tissue activated and comparing aggregated spatial data and calculated probability maps to forecast gait performance and the parkinsonism control. 42 patients experienced improvement of presurgical gait problems after stimulation. Seven patients showed gait deteriorations one-year post-implantation. Active contacts were more ventrally located for gait deterioration versus gait improvement. Voxel-wise probabilistic mapping of gait changes in the subthalamic area were able to forecast patient specific gait performance based on individual stimulation volume (LOOCV R = 0. 45; p
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | gait |
| disease | MESH | Parkinson’s disease |
| disease | MESH | parkinsonism |
| disease | MESH | Gait Disorders Neurologic |
| disease | MESH | Movement disorder |
| pathway | KEGG | Parkinson disease |