A Phase II Double-Blind Trial of Sulforaphane for Therapeutic Prevention of Melanoma in Patients With Multiple Atypical Nevi and a Prior History of Melanoma

Publication date: Jun 24, 2025

The goal of this clinical trial is to compare the safety and effects of sulforaphane with the safety and effects of placebo on people’s risk of developing melanoma. The main question it aims to answer is: Will giving sulforaphane (a broccoli sprout extract) have a meaningful effect on how your atypical moles change over time? If there is an effect, will this lower your risk of developing melanoma? Participants will: Take sulforaphane or a placebo for 12 months Visit the clinic once every 3 months for checkups and tests You will keep a calendar which will help you keep track of when you take your tablets

Concepts Keywords
Blind Melanoma
Immunotherapy Skin Neoplasm
Months
Stage
Vegetables

Semantics

Type Source Name
drug DRUGBANK Sulforaphane
disease MESH Melanoma
pathway KEGG Melanoma
disease MESH Nevi
disease MESH Cancer
disease MESH relapse
disease MESH viral load
disease MESH infection
disease MESH allergy
disease MESH Skin Neoplasm

Original Article

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