Publication date: Jun 26, 2025
Chronic masticatory muscle pain (CMMP), a common symptom of temporomandibular disorders (TMD), is influenced by numerous factors. Central sensitisation (CS) is a significant factor in both chronic pain and temporomandibular disorders. Psychological aspects like anxiety and depression are known to exacerbate pain symptoms. However, the interplay between CS and these factors in CMMP remains unclear. The objective of this study was to evaluate the relationship between CS, anxiety and depressive symptoms in patients with CMMP and to assess how they correlate. A total of 206 patients with CMMP underwent a clinical examination following the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and completed the Central Sensitisation Inventory (CSI), Patient Health Questionnaire-9 (PHQ-9) and Generalised Anxiety Disorder-7 (GAD-7) questionnaires. Pain severity was assessed using the Graded Chronic Pain Scale (GCPS) and the Numeric Rating Scale (NRS). Statistical analyses were conducted to examine correlations and group differences. Significant correlations were found between CSI and both PHQ-9 (r = 0. 719, p
| Concepts | Keywords |
|---|---|
| Depressive | anxiety |
| Masticatory | central sensitisation |
| Patient | chronic pain |
| Temporomandibular | masticatory muscle pain |
| orofacial pain | |
| temporomandibular disorders |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Anxiety |
| disease | MESH | Depressive Symptoms |
| disease | MESH | temporomandibular disorders |
| disease | MESH | chronic pain |
| disease | MESH | Anxiety Disorder |