Publication date: Jun 28, 2025
“Pleiotropy and uncommon variantsOver the past few years, scientists have found that there are common genetic threads that may be linking and causing coexisting psychiatric disorders. “From twin studies to genome-wide association studiesLife experiences, environment, and genetics can all influence psychiatric disorders, but much of it comes down to variations in our genetics. The article introduces next steps for the consortium and describes major findings from the past half-decade by the group of researchers. Those locations are then said to be associated with the disorder or trait under study. Of them, 109 of the hot spots were shared among multiple disorders, or were deemed “pleiotropic. “Our work will drive advancements across the field, establish a robust platform for future research, inspire innovation, and promote collaborative, transparent, and reproducible science to enhance clinical impact. This article has been reviewed according to Science X’s editorial process and policies .
| Concepts | Keywords |
|---|---|
| Decade | Autism |
| Nutrition | Disorder |
| Researchers | Disorders |
| Schizophrenia | Eating |
| Genetic | |
| Genome | |
| Group | |
| Locations | |
| Major | |
| Multiple | |
| Pgc | |
| Psychiatric | |
| Schizophrenia | |
| Substance | |
| Years |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | Digestion |
| pathway | REACTOME | Metabolism |
| drug | DRUGBANK | Benzylpenicillin |
| disease | MESH | neurodevelopmental disorders |
| disease | MESH | epilepsy |
| disease | MESH | eating disorders |
| disease | MESH | depression |
| disease | MESH | schizophrenia |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | Psychiatric disorders |
| disease | MESH | intellectual disability |
| drug | DRUGBANK | Medical Cannabis |
| disease | MESH | Autism spectrum disorder |
| disease | MESH | Substance use |
| drug | DRUGBANK | Ethanol |
| disease | MESH | obsessive-compulsive disorder |
| disease | MESH | Tourette syndrome |
| disease | MESH | bipolar disorder |
| disease | MESH | anorexia nervosa |
| disease | MESH | major depressive disorder |