Publication date: Jun 29, 2025
Summary: Researchers have uncovered how losing the autism-linked gene PTEN in a specific set of inhibitory neurons reshapes brain circuits tied to fear and anxiety. Specifically, this manipulation decreased the strength of connections between individual neurons and altered the distribution of local connections in a cell-type specific manner. Credit: Neuroscience NewsPTEN has emerged as one of the most significant autism risk genes.
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | macrocephaly |
| disease | MESH | haploinsufficiency |
| disease | MESH | autism spectrum disorder |
| disease | MESH | neurological disorders |
| drug | DRUGBANK | Somatostatin |
| disease | MESH | autism |
| disease | MESH | Anxiety |
Original Article
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