Plasma Matrix Metalloproteinases Signature as Biomarkers for Pediatric Tuberculosis Diagnosis: A Prospective Case-Control Study.

ingentiumby ingentium

In Tuberculosis Literature.

Publication date: May 27, 2025

Diagnosing tuberculosis (TB) in children presents significant challenges, necessitating the identification of reliable biomarkers for accurate diagnosis. In this study, we investigated plasma matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as potential diagnostic markers. A prospective case-control study involved 167 children classified into confirmed TB, unconfirmed TB, and unlikely TB control groups. Plasma levels of MMPs (MMP 1, 2, 3, 7, 8, 9, 12, and 13) and TIMPs (TIMP 1, 2, 3, and 4) were measured using multiplex assays. Elevated baseline levels of MMP-1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 were observed in active TB cases compared to unlikely TB controls. Receiver operating characteristics (ROC) analysis identified MMP-1, MMP-2, MMP-9, and TIMP-1 as potential biomarkers with over 80% sensitivity and specificity. A three-MMP signature (MMP-1, MMP-2, and MMP-9) demonstrated 100% sensitivity and specificity. The findings suggest that a baseline MMP signature could serve as an accurate biomarker for diagnosing pediatric TB, enabling early intervention and effective management.

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Concepts Keywords
Biomarker biomarkers
Pediatric MMPs
Receiver tuberculosis
Tuberculosis

Semantics

Type Source Name
disease MESH Tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Saquinavir
disease IDO intervention
drug DRUGBANK Coenzyme M
disease MESH Parasitic Diseases
disease MESH Allergy
disease MESH Infectious Diseases
disease IDO host
disease IDO blood
disease MESH inflammation
disease MESH treatment failure
disease MESH relapse
disease MESH death
disease MESH tic
disease IDO history
drug DRUGBANK 5-amino-1 3 4-thiadiazole-2-thiol
disease MESH COPD
disease MESH viral pneumonia
disease MESH bacterial pneumonia
disease MESH asthma
pathway KEGG Asthma
disease IDO assay
disease IDO susceptibility
disease MESH nutritional status
disease MESH infection
disease MESH pulmonary tuberculosis
drug DRUGBANK Dimercaprol
disease MESH respiratory infections
disease MESH pneumonia
disease MESH diabetes mellitus
drug DRUGBANK Etoperidone
disease IDO country
disease MESH idiopathic pulmonary fibrosis
disease MESH extrapulmonary tuberculosis
disease MESH morbidity
drug DRUGBANK Metformin
disease MESH tuberculous meningitis
disease MESH pleuritis

Original Article

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