The Adverse Effects of Tuberculosis Treatment: A Comprehensive Literature Review.

ingentiumby ingentium

In Tuberculosis Literature.

Publication date: May 17, 2025

Tuberculosis remains a significant public health challenge globally. The emergence of multidrug-resistant Mycobacterium tuberculosis strains presents one of the biggest hurdles in tuberculosis management. Both first- and second-line tuberculosis drugs are associated with common adverse reactions, which can lead to treatment interruptions and decreased adherence. In this article, we review the most commonly used drugs for the treatment of tuberculosis, focusing on the adverse reactions they may cause. We will examine the frequency and timeline of adverse drug reactions involving gastrointestinal, cardiac, neurological, nephrological, and cutaneous systems. Identifying patients at risk of developing those reactions is crucial for healthcare providers to implement monitoring strategies and manage complications effectively. In the review, we present the data about risk factors, management recommendations, and drug discontinuation rates as a result of side effects.

Open Access PDF

Concepts Keywords
Globally adverse drug reactions
Healthcare Antitubercular Agents
Kaunas Antitubercular Agents
Mycobacterium drug-resistant tuberculosis
Tuberculosis drug-susceptible tuberculosis
first-line drugs
Humans
Risk Factors
second-line drugs
Tuberculosis
tuberculosis
Tuberculosis, Multidrug-Resistant

Semantics

Type Source Name
disease MESH Tuberculosis
pathway KEGG Tuberculosis
disease MESH adverse drug reactions
disease MESH complications
disease MESH death
disease IDO infectious agent
drug DRUGBANK Rifampicin
drug DRUGBANK Isoniazid
drug DRUGBANK Ethambutol
drug DRUGBANK Pyrazinamide
disease MESH extensively drug resistant tuberculosis
drug DRUGBANK Bedaquiline
drug DRUGBANK Delamanid
drug DRUGBANK Pretomanid
disease MESH latent tuberculosis
drug DRUGBANK Niacin
drug DRUGBANK NADH
disease IDO process
disease IDO nucleic acid
disease IDO protein
disease IDO bacteria
drug DRUGBANK Phenoxypropazine
drug DRUGBANK Pyridoxine
pathway KEGG Vitamin B6 metabolism
disease MESH peripheral neuropathy
disease MESH syndrome
disease MESH Psychosis
disease MESH optic neuritis
disease MESH pancreatitis
drug DRUGBANK Phenytoin
drug DRUGBANK Carbamazepine
drug DRUGBANK Warfarin
drug DRUGBANK Theophylline
drug DRUGBANK Ethanol
disease MESH liver disease
disease MESH hepatitis
disease MESH HIV infection
pathway REACTOME HIV Infection
disease MESH uremia
disease MESH malnutrition
disease MESH alcoholism
pathway KEGG Alcoholism
disease MESH abnormalities
disease MESH mania
disease MESH hypersensitivity
disease MESH neurological disorders
disease MESH psychiatric disorders
drug DRUGBANK Rifamycin
pathway REACTOME Metabolism
disease MESH thrombocytopenia
disease MESH acute renal failure
disease MESH hemolytic anemia
disease MESH pseudomembranous colitis
drug DRUGBANK Digoxin
drug DRUGBANK Methadone
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Nicotinamide
drug DRUGBANK Uric Acid
disease MESH hyperuricemia
disease MESH joint pain
disease MESH gastrointestinal disorders
disease MESH gout
disease MESH rhabdomyolysis
disease MESH toxic epidermal necrolysis
disease MESH drug interactions
drug DRUGBANK Allopurinol
drug DRUGBANK Probenecid
drug DRUGBANK Ciclosporin
disease MESH diabetes mellitus
disease MESH Optic neuropathy
drug DRUGBANK Aluminium
drug DRUGBANK Ethionamide
disease IDO blood
drug DRUGBANK Coenzyme M
drug DRUGBANK Moxifloxacin
drug DRUGBANK Rifapentine
drug DRUGBANK Aluminum hydroxide
drug DRUGBANK Valproic Acid
drug DRUGBANK Diazepam
drug DRUGBANK Levodopa
drug DRUGBANK Enflurane
drug DRUGBANK Ketoconazole
drug DRUGBANK Cycloserine
drug DRUGBANK Disulfiram
drug DRUGBANK Acetaminophen
disease MESH Hepatic porphyria
drug DRUGBANK Protoporphyrin
drug DRUGBANK Amiodarone
drug DRUGBANK Codeine
drug DRUGBANK Dapsone
drug DRUGBANK Diltiazem
drug DRUGBANK Enalapril
drug DRUGBANK Fluconazole
drug DRUGBANK Haloperidol
drug DRUGBANK Itraconazole
drug DRUGBANK Morphine
drug DRUGBANK Propafenone
drug DRUGBANK Nifedipine
drug DRUGBANK Quinidine
drug DRUGBANK Verapamil
drug DRUGBANK Efavirenz
drug DRUGBANK Indinavir
drug DRUGBANK Lopinavir
drug DRUGBANK Ritonavir
drug DRUGBANK Nelfinavir
drug DRUGBANK Saquinavir
drug DRUGBANK Zidovudine
drug DRUGBANK Colchicine
disease MESH kidney disease
drug DRUGBANK Didanosine
drug DRUGBANK Zalcitabine
disease MESH peripheral neuritis
pathway REACTOME Potassium Channels
disease IDO production
drug DRUGBANK Oxygen
drug DRUGBANK Sucralfate
disease MESH convulsions
disease MESH cardiac diseases
disease MESH renal insufficiency
drug DRUGBANK Linezolid
drug DRUGBANK Clofazimine
pathway REACTOME Killing mechanisms
drug DRUGBANK Metoclopramide
drug DRUGBANK Furosemide
drug DRUGBANK Hydrochlorothiazide
drug DRUGBANK Citalopram
drug DRUGBANK Escitalopram
drug DRUGBANK Terizidone
drug DRUGBANK L-Alanine
drug DRUGBANK Meropenem
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK Ganciclovir
drug DRUGBANK Imipenem
disease IDO history
drug DRUGBANK Amikacin
pathway REACTOME Translation
drug DRUGBANK Acyclovir
drug DRUGBANK Amphotericin B
drug DRUGBANK Cisplatin
drug DRUGBANK Etacrynic acid
disease MESH ototoxicity
drug DRUGBANK Capreomycin
drug DRUGBANK Methotrexate
drug DRUGBANK Vancomycin
disease MESH dehydration
disease MESH hearing impairment
drug DRUGBANK Protionamide
pathway KEGG Mycolic acid biosynthesis
disease MESH hypothyroidism
drug DRUGBANK Folic Acid
pathway KEGG Thyroid hormone synthesis
drug DRUGBANK Cyanocobalamin
drug DRUGBANK ATP
disease MESH Mitochondrial dysfunction
disease MESH Hypoalbuminemia
drug DRUGBANK Diethylstilbestrol
drug DRUGBANK Nitric Oxide
disease MESH depression
disease MESH dysarthria
disease MESH vasculitis
disease MESH anemia
drug DRUGBANK Creatinine
disease MESH hepatitis B
pathway KEGG Hepatitis B
disease MESH DRESS syndrome
disease MESH sideroblastic anemia
drug DRUGBANK Levofloxacin
disease MESH insomnia
disease MESH arrhythmia
disease MESH hallucinations
disease MESH delusions
disease MESH urticaria
drug DRUGBANK Potassium
disease MESH lactic acidosis
disease MESH hyperlactatemia
disease MESH hypotension
disease MESH ichthyosis
disease MESH acne
disease MESH tremors
disease MESH anxiety
disease MESH confusion
disease MESH numbness
disease MESH leprosy
drug DRUGBANK Guanine
disease MESH sudden cardiac death
disease MESH drug-resistant tuberculosis

Original Article

(Visited 10 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *