Publication date: Jul 03, 2025
Now, an international team, led by researchers from Lund University, has identified that certain aggressive melanoma tumours rely heavily on two critical mitochondrial processes. Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies. Melanoma remains the most aggressive form of skin cancer. The findings point to a promising avenue for combination therapy with drugs already approved and available for other indications. However, their involvement in melanoma progression has previously received limited attention. Despite major advances in immunotherapy, effective treatments for patients with advanced melanomas are still limited. But we have not conducted any clinical trials; those will be needed to see if this will also work in humans.
| Concepts | Keywords |
|---|---|
| Cancer | Activity |
| Driving | Aggressive |
| Relapse | Approved |
| Stage | Cancer |
| Drugs | |
| Energy | |
| Findings | |
| Melanoma | |
| Mitochondrial | |
| Processes | |
| Production | |
| Skin | |
| Synthesis | |
| Treatment | |
| Tumours |
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | Release |
| disease | MESH | relapse |
| drug | DRUGBANK | Azithromycin |
| drug | DRUGBANK | Tigecycline |
| drug | DRUGBANK | Doxycycline |
| pathway | KEGG | Oxidative phosphorylation |
| disease | MESH | CANCER |
| pathway | KEGG | Melanoma |
| disease | MESH | Melanoma |
| disease | MESH | Skin Cancer |