Publication date: Jul 02, 2025
Major depressive disorder (MDD) is a prevalent mental health problem among adolescents, with non-suicidal self-injury (NSSI) behaviors representing a prominent symptomatic manifestation. There is growing evidence that NSSI is associated with childhood maltreatment (CM) and inflammatory cytokines. However, these associations have not been sufficiently researched in adolescents with MDD. This study aimed to investigate such associations in depressed adolescents. The Centre for Epidemiological Studies Depression Scale (CES-D) and the Childhood Trauma Questionnaire (CTQ) were used to assess depressive symptoms and CM, respectively. Additionally, plasma levels of interleukin (IL)-1β, IL-6, IL-10, IL-17 A, and tumor necrosis factor-α (TNF-α) were measured. The detection rate of NSSI in adolescents with MDD was 63. 8%. Patients with NSSI had higher scores of CES-D and CTQ as well as inflammatory cytokines levels (especially IL-1β) than non-NSSI patients (all p
Open Access PDF
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | major depressive disorder |
| disease | MESH | Depression |
| drug | DRUGBANK | Interleukin-10 |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | Adverse Childhood Experiences |
| disease | MESH | Child Abuse |