Publication date: Jul 03, 2025
Severe respiratory failure often requires invasive mechanical ventilation, identifying the factors that lead to this need is crucial. This study aims to identify risk factors for invasive mechanical ventilation and clinical outcomes in patients with acute respiratory failure from the time of onset of symptoms to respiratory failure. This retrospective cohort included adults with confirmed COVID-19 admitted to Intermediate or Intensive Care Units between May 1, 2020, and May 1, 2021. Inclusion required chest computed tomography (CT) and inflammatory markers (CRP, D-dimer, ferritin, IL-6) within 72 h of admission. The primary outcome was the need for orotracheal intubation and its association with mortality. Multivariate Cox regression and time-stratified analyses were performed. Of 550 patients, 346 (63%) required intubation. The overall in-hospital mortality rate was 21. 6%. Intubated patients had higher BMI (p = 0. 02), SAPS-3 scores (p 
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | respiratory failure |
| disease | MESH | COVID-19 |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Trestolone |
| disease | IDO | process |
| drug | DRUGBANK | Esomeprazole |