Publication date: Jul 04, 2025
This study will identify cortical proteins that may provide motor resilience, the capacity to maintain motor function despite underlying ADRD pathologies. We studied 850 decedents with postmortem indices of ten ADRD pathologies and proteome from dorsal lateral prefrontal cortex. Annual parkinsonian signs were assessed using a modified Unified Parkinson Disease Rating Scale. First, we adjusted linear models for ADRD pathologies to isolate resilience proteins, unrelated to ADRD pathologies, but that were related to linear motor decline. Next, functional mixed-effects (FME) models were used to determine if resilience proteins were related to non-linear motor decline. Exploratory functional enrichment was then used to assess pathways underlying motor resilience proteins. Mean age at death was 90 years (SD = 6. 4), 69% female and 7 years follow-up. Adjusting linear models for age, sex and ADRD pathologies, we isolated thirteen proteins that may provide motor resilience (Bonferroni correction p 
| Concepts | Keywords |
|---|---|
| Annual | ADRD pathologies |
| Death | Motor decline |
| Models | parkinsonism |
| Older | resilience proteins |
| Parkinsonian | time course |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Pentaerythritol tetranitrate |
| disease | MESH | Parkinson Disease |
| pathway | KEGG | Parkinson disease |
| disease | MESH | death |
| disease | MESH | parkinsonism |