Publication date: Dec 01, 2025
To assess the impact of low-dose intravenous esketamine on postpartum depression scores in women undergoing cesarean section. In a randomized, double-blind, placebo-controlled trial, 186 women aged 20-50 years receiving epidural anesthesia for cesarean section were divided into three groups: Group A (0. 25 mg/kg esketamine intraoperatively + esketamine in PCIA), Group B (0. 25 mg/kg esketamine intraoperatively + PCIA without esketamine), and Group C (placebo intraoperatively + PCIA without esketamine). The primary outcome was the change in Edinburgh Postnatal Depression Scale (EPDS) scores. Secondary outcomes included Pittsburgh Sleep Quality Index (PSQI) scores, Visual Analogue Scale (VAS) scores, PCIA bolus frequency, and adverse events. EPDS and PSQI scores decreased significantly post-surgery across all groups (p
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Esketamine |
| disease | MESH | depression |
| disease | MESH | postpartum depression |
| drug | DRUGBANK | Ketamine |