Publication date: Jul 04, 2025
The use of propranolol in the treatment of panic attacks has historically been widespread. However, there is insufficient precise evidence regarding the combination of propranolol with sertraline in this context. Panic attacks are a common health issue among women, significantly affecting their personal and social lives. Therefore, this study aimed to determine the effect of sertraline, with or without propranolol, on the severity of panic attack symptoms and depressive symptoms. This randomized controlled clinical trial included 60 women who attended a specialized university clinic in Tabriz. Participants were randomly assigned to either the sertraline with propranolol group (n = 30) or the sertraline with propranolol placebo group (n = 30) using block randomization method. Both groups received drugs for four weeks. Data were collected using the Panic Disorder Severity Scale- Self-Report (PDSS-SR) and the Beck Depression Inventory-Short Form (BDI-13). The Mann-Whitney U test was employed to compare outcomes between the two groups, and Wilcoxon tests were used for within-group comparisons. Samples were enrolled from July 22, 2024, to February 11, 2025. The two groups exhibited no statistically significant differences in sociodemographic characteristics (p > 0. 05). After the intervention, the mean score for the severity of panic attack symptoms in the sertraline with propranolol group was 6. 6 (SD: 4. 4), compared to 13. 1 (SD: 5. 4) in the sertraline with propranolol placebo group, indicating a statistically significant difference (P 
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| Concepts | Keywords |
|---|---|
| Depressive | Depression |
| February | Panic attacks |
| July | Propranolol |
| Women | Sertraline |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Sertraline |
| drug | DRUGBANK | Propranolol |
| disease | MESH | panic attacks |
| disease | MESH | depressive symptoms |