Exposure to pesticides and increased risk of AMD

Publication date: Jul 06, 2025

PFI and SHAP analyses indicated that DAP metabolites were of significant contribution weights in AMD risk prediction, higher than most of the sociodemographic covariates. Shapley values and waterfall plots of randomly selected AMD individuals emphasized the predictive capacity of ML with high accuracy and sensitivity in each case. For example, several researchers have emphasized the impacts of heavy metals,3 air pollutants,4 and radiation5 exposure on the development of AMD. Receiver operating characteristic curve analysis evaluated Random Forests as the best ML model with its optimal predictive performance among 11 models.

Concepts	Keywords
China	Amd
Diabetes13	Dap
Effective	Diseases
Insecticides	Environmental
Ophthalmology	Exposure
	Factors
	Investigators
	Metabolites
	Opps
	Pesticides
	Phosphate
	Prediction
	Risk
	Shanghai
	Urinary

Semantics

Type	Source	Name
drug	DRUGBANK	Methyldopa
disease	MESH	age-related macular degeneration
drug	DRUGBANK	Phosphate ion
drug	DRUGBANK	Amifampridine
disease	MESH	Eye Diseases
disease	MESH	lifestyle
disease	MESH	pathogenesis
disease	MESH	complications
drug	DRUGBANK	Water
disease	MESH	cancer
disease	MESH	central nervous system disorders
disease	MESH	depression
disease	MESH	hypertension