Publication date: Jul 05, 2025
The diagnosis of Parkinson’s disease (PD) lacks reliable biomarkers. This study investigated substantia nigra (SN) elasticity using shear wave elastography (SWE) as a novel diagnostic tool for PD. To investigate the role of SN elasticity values in the diagnosis of PD and their correlation with disease severity, duration, and iron metabolism indicators. This study included PD patients diagnosed and treated at Tongji Hospital’s Neurology Department and healthy controls from January 2021 to December 2022. SWE was used to measure the elasticity of the SN and surrounding midbrain regions. Differences in elasticity between the two groups were analyzed, along with correlations between SN elasticity and age, hyperechoic area of SN, iron metabolism markers, and disease duration. A total of 90 patients with PD and 106 healthy controls who could undergo transcranial ultrasound elastography were enrolled. The PD group demonstrated significantly elevated SN elasticity values (20. 43 +/- 3. 94 kPa vs. 10. 72 +/- 1. 86 kPa, P
| Concepts | Keywords |
|---|---|
| Biomarker | Parkinson’s disease |
| December | substantia nigra |
| Parkinson | |
| Reliable |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Parkinson’s Disease |
| drug | DRUGBANK | Iron |
| pathway | REACTOME | Metabolism |