Association between maternal asthma and ASD/ADHD in offspring: A meta-analysis based on observational studies.

ingentiumby ingentium

In Autism Literature.

Publication date: Jul 08, 2025

This meta-analysis aims to examine the association between maternal asthma and autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD) in offspring. A literature search was performed in PubMed, Web of Science, Embase, and the Cochrane Library from electronic database inception to October 2024 for studies on the relationship between asthma and ASD/ADHD. The definition of maternal asthma was “asthma existing prior to childbirth”. The primary outcome was the incidence of ASD/ADHD in the offspring. This meta-analysis incorporated 5 cohort studies and 7 case-control studies. The statistical results suggested that there is a higher incidence of ASD (odds ratio (OR) = 1. 36, 95% confidence interval (95%CI) = 1. 28-1. 44, P 

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Concepts Keywords
Autism Asthma
Childbirth Autism Spectrum Disorder
Library Female
October Humans
Performed Incidence
Male
Pregnancy
Pregnancy Complications

Semantics

Type Source Name
disease MESH asthma
pathway KEGG Asthma
disease MESH ADHD
disease MESH autism spectrum disorder
disease MESH Neurodevelopmental disorders
disease MESH etiology
drug DRUGBANK Coenzyme M
drug DRUGBANK Methionine
drug DRUGBANK Serotonin
pathway KEGG Tryptophan metabolism
disease MESH autism
pathway REACTOME Metabolism
disease MESH Mitochondrial dysfunction
pathway KEGG Oxidative phosphorylation
drug DRUGBANK ATP
drug DRUGBANK Glutamic Acid
disease MESH anxiety
drug DRUGBANK Testosterone
drug DRUGBANK Trestolone
disease MESH clinical relevance
disease MESH neuroinflammation
disease MESH autoimmune diseases
disease MESH allergies
disease MESH immune system diseases
disease MESH inflammation
drug DRUGBANK Medical air
pathway REACTOME Serotonin receptors
disease MESH depression
disease MESH schizophrenia
disease MESH bipolar disorder
pathway REACTOME Immune System
disease MESH Alcoholic Fatty Liver
disease MESH NAFLD
disease MESH metabolic diseases
drug DRUGBANK Guanosine
disease MESH abnormalities
drug DRUGBANK Fluoxetine
disease MESH mental disorders
disease MESH oxidative stress
pathway REACTOME Autophagy
drug DRUGBANK Calcium
pathway REACTOME Apoptosis
disease MESH premature aging
pathway REACTOME Glycolysis
disease MESH Alzheimer’s disease
disease MESH dysbiosis
disease MESH eczema
disease MESH phoria
disease MESH aneuploidies
pathway REACTOME Reproduction
disease MESH Pregnancy Complications

Original Article

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