Publication date: Jul 08, 2025
iPSCs are produced through a method that adds molecules to turn adult cells, like skin cells, back into stem cells. While mitochondria can change their shape in a healthy cell too, it can also be a further indicator that these cells may be damaged or stressed. Ultimately, this could be damaging for cells and impact the way the brain develops. Mitochondria form complex networks within the cell and are also very active. The study looked at different gene signatures between iPSCs, neural progenitor cells, and mini-brains at two different ages, with and without the gene for HD. Because mitochondria are so important for the cell, they frequently undergo rigorous quality control, where damaged mitochondria are degraded within the cell. Essentially, the research team seemed to identify a stress response related to mitochondria caused by HD thats present even at very early stages of development. Using this approach, new work is advancing what we know about HD. One limitation of neurons grown from stem cells is that theyre typically grown on a two-dimensional plastic surface.
| Concepts | Keywords |
|---|---|
| Death | Brain |
| Healthy | Brains |
| Huntingtons | Cell |
| Neurodevelopment | Cells |
| Yale | Chchd2 |
| Early | |
| Energy | |
| Found | |
| Grown | |
| Hd | |
| Mini | |
| Mitochondria | |
| Neurons | |
| Progenitor | |
| Stem |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | death |
| drug | DRUGBANK | Tropicamide |
| disease | MESH | defects |
| disease | MESH | seizures |
| disease | MESH | brain diseases |
| disease | MESH | causes |
| disease | MESH | Huntington’s disease |
| drug | DRUGBANK | Isoxaflutole |