Explainable deep learning approaches for high precision early melanoma detection using dermoscopic images.

Publication date: Jul 08, 2025

Detecting skin melanoma in the early stage using dermoscopic images presents a complex challenge due to the inherent variability in images. Utilizing dermatology datasets, the study aimed to develop Automated Diagnostic Systems for early skin cancer detection. Existing methods often struggle with diverse skin types, cancer stages, and imaging conditions, highlighting a critical gap in reliability and explainability. The novel approach proposed through this research addresses this gap by utilizing a proposed model with advanced layers, including Global Average Pooling, Batch Normalization, Dropout, and dense layers with ReLU and Swish activations to improve model performance. The proposed model achieved accuracies of 95. 23% and 96. 48% for the two different datasets, demonstrating its robustness, reliability, and strong performance across other performance metrics. Explainable AI techniques such as Gradient-weighted Class Activation Mapping and Saliency Maps offered insights into the model’s decision- making process. These advancements enhance skin cancer diagnostics, provide medical experts with resources for early detection, improve clinical outcomes, and increase acceptance of Deep Learning-based diagnostics in healthcare.

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Concepts Keywords
Dermatology Deep Learning
Diagnostics Deep learning
Global Dermoscopic images
Pooling Dermoscopy
Stage Early-stage melanoma detection
Explainable AI
Humans
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
Melanoma
Reproducibility of Results
Skin Neoplasms
Swish activation

Semantics

Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
disease MESH skin cancer
disease MESH cancer
drug DRUGBANK Flunarizine
disease MESH infections
drug DRUGBANK Honey
disease MESH melanocytic nevi
disease MESH carcinoma
disease MESH squamous carcinoma
disease MESH nevi
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH skin disease
disease MESH misdiagnosis
disease MESH ischemic stroke
disease MESH skin abnormalities
disease MESH aids
disease MESH confusion
drug DRUGBANK Oxybuprocaine
drug DRUGBANK Isoxaflutole
drug DRUGBANK Aspartame
disease MESH complications
drug DRUGBANK Tropicamide
disease MESH causes
disease MESH covid 19
disease MESH pneumothorax
disease MESH pneumonia
disease MESH lung cancer
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Nonoxynol-9
disease MESH seborrheic keratosis
disease MESH stroke
drug DRUGBANK Oxymetazoline
pathway REACTOME Reproduction

Original Article

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