Publication date: Jul 08, 2025
Denmark has monitored invasive pneumococcal diseases (IPD) for decades, observing shifts in serotype prevalence, partly due to pneumococcal conjugate vaccines in children. The COVID-19 pandemic and the Danish government’s 2020 vaccination program with the 23-valent pneumococcal polysaccharide vaccine (PPV23) for older adults further influenced IPD epidemiology. This study explores the dynamics of Global Pneumococcal Sequence Clusters (GPSCs) in Denmark from 2019 to 2023 using whole-genome sequencing (WGS) on IPD isolates from all age groups received at Statens Serum Institut (SSI). Serotyping, multilocus sequence typing (MLST), GPSC identification, and phylogenetic analysis to assess clonal relationships were conducted. Of the 1,999 sequenced isolates, representing 93. 3% of reported cases, 79 different GPSCs were identified, with GPSC3, GPSC12, and GPSC19 being dominant. GPSC3/ST53 (serotype 8) declined significantly from 24. 6% in 2019 to 14. 4% in 2023 (p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | pneumococcal diseases |
| disease | MESH | COVID-19 pandemic |
| disease | IDO | pathogen |
| disease | IDO | blood |
| drug | DRUGBANK | Coenzyme M |