Publication date: Jul 10, 2025
Approximately 37% of the study participants were assigned to this subtype. Mixed ASD with developmental delay: Individuals in this group will often reach developmental milestones later than children without ASD. Approximately 19% of the study participants were assigned to this subtype. Moderate challenges: Individuals may show core autism traits, but less than individuals in the other groups. Approximately 10% of the study participants were assigned to this subtype. The data point to specific mechanisms underpinning similar clinical presentations of ASD. Despite progress in uncovering ASD-related genes, a unified map connecting genetic variation to clinical phenotypes is still lacking. They typically reach developmental milestones at a similar pace to people without ASD and do not experience other psychiatric conditions. Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs. For instance, the highest number of de novo mutations was identified in the broadly affected group.
| Concepts | Keywords |
|---|---|
| Autism | Asd |
| Biology | Author |
| President | Autism |
| Tailoring | Challenges |
| Clinical | |
| Co | |
| Developmental | |
| Genetic | |
| Individuals | |
| Inherited | |
| Mixed | |
| Social | |
| Subtype | |
| Subtypes | |
| Traits |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Autism |
| disease | MESH | disruptive behaviors |
| disease | MESH | depression |
| disease | MESH | autism spectrum disorder |
| disease | MESH | causes |
| disease | MESH | anxiety |