Publication date: Jul 10, 2025
One slightly more moderately powered study in migraine patients identified increased bilateral amygdala volume in both patients with migraine alone or migraine with depression . In migraine, dopamine has been implicated as playing a role clinically, hormonally, and genetically across multiple phases of migraine, including interictal periods [142, 143]. As a prophylactic treatment for migraine, approximately 10% of topiramate-treated patients experience depression, and depression risk increases significantly in patients with a history of depression [103, 104]. In the case of migraine, chronic and repeated stress is thought to lower the sensitivity threshold to otherwise innocuous stimuli, triggering migraine attacks . In the case of migraine, elevated levels of CGRP is a target for treatments that abort and/or prevent migraine in some patients [40, 69]. Within the context of migraine, the LC-norepinephrine system appears to play an important role in trigeminal sensitization and migraine [222, 244]. Related studies strongly implicate adrenergic neural circuits, which play an important role in the development of depression as well as migraine (as discussed above) [242, 330, 331].
| Concepts | Keywords |
|---|---|
| Homeostasis | Brain |
| Migraine | Depression |
| Mri | Depressive |
| Disorders | |
| Increased | |
| Mdd | |
| Mechanisms | |
| Migraine | |
| Pacap | |
| Pain | |
| Regulation | |
| Sensory | |
| Serotonin | |
| Shown | |
| Stress |