Publication date: Jul 09, 2025
Multiple severe acute respiratory syndrome (SARS-CoV-2) exposures either due to infection or vaccination result in differential immune responses. Limited data exist on community-level SARS-CoV-2 variant exposures in India. We assessed antibody levels in 211 unvaccinated and 349 vaccinated individuals with and without prior exposure, followed for ~ 2 years (May 2021-October 2023) with baseline blood, weekly saliva for RT-PCR, and blood draws at ~ 6, 12, and 24 months. Humoral and cellular immune responses following primary (N = 8) and secondary (N = 11) Omicron infections in unvaccinated, previously exposed (N = 25), and unexposed vaccinated (N = 14) individuals were evaluated using Meso Scale Discovery and flow cytometry assays at Day 0, 30, and 90. Previously exposed individuals had higher anti-spike IgG levels at baseline (median 57,732 vs. 11,359, p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | infection |
| disease | MESH | severe acute respiratory syndrome |
| disease | IDO | blood |
| disease | MESH | COVID-19 |