Publication date: Jul 11, 2025
These insights could inform future vaccine development strategiesparticularly those targeting broad-spectrum protection or tailored to individual immune profiles. The Bacillus CalmetteGurin (BCG) vaccine, in use for nearly a century to protect against tuberculosis, has long intrigued scientists for its ability to confer nonspecific protection against other infections. They found that BCG leaves a distinctive methylation signature persisting well beyond the initial vaccination period.
| Concepts | Keywords |
|---|---|
| Hannover | Bcg |
| Trains | Centre |
| Tuberculosis | Ciim |
| Vaccine | Epigenetic |
| Women | Genetic |
| Hannover | |
| Immune | |
| Immunity | |
| Infection | |
| Infections | |
| Methylation | |
| Protection | |
| Response | |
| Vaccination | |
| Vaccine |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | BCG vaccine |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | infections |
| disease | IDO | infection |
| pathway | REACTOME | DNA methylation |
| disease | IDO | cell |
| pathway | REACTOME | Methylation |
| disease | IDO | pathogen |
| pathway | REACTOME | Immune System |
| pathway | REACTOME | Reproduction |
| disease | IDO | immune response |
Original Article
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