Publication date: Dec 01, 2025
We aimed to assess whether soluble programmed death-ligand 1 (sPD-L1) could serve as a new biomarker for PTB. Plasma sPD-L1 levels in the discovery cohort were analyzed through flow cytometry and validated by sandwich ELISA. Pleural effusion sPD-L1 levels were measured using ELISA. In the discovery cohort, sPD-L1 levels in the severe (SE, n = 44), non-severe (non-SE, n = 34) and HC (n = 10) group were 67. 41 (30. 14-126. 41), 26. 75 (11. 00-52. 35) and 14. 6 (10. 78-21. 91) pg/ml, respectively. The sPD-L1 levels in SE patients were significantly higher than those in both non-SE patients and HCs (p
Semantics
| Type | Source | Name |
|---|---|---|
| pathway | REACTOME | Programmed Cell Death |
| disease | MESH | pulmonary tuberculosis |
| disease | MESH | death |
| disease | MESH | Pleural effusion |
| disease | IDO | assay |
| drug | DRUGBANK | Saquinavir |
Original Article
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