Publication date: Dec 10, 2025
The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt. We assessed age-specific antibody dynamics across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2 using serology collected in King County, Washington, US, from 2020-2022 (n = 1508). We found that respiratory virus immunodynamics differed between individuals
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| Concepts | Keywords |
|---|---|
| Atypical | Age |
| Coronaviruses | Covid |
| Immunodynamics | Dynamics |
| Multiplex | Immunodynamics |
| Multiplex | |
| Pandemic | |
| Pathogens | |
| Rebound | |
| Respiratory | |
| Reveals | |
| Serology | |
| Specific | |
| Virus | |
| Viruses | |
| Wake |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 pandemic |
| disease | MESH | influenza |
Original Article
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