Web-based high-intensity bodyweight interval training improves metabolic health and physical fitness outcomes in middle-aged men with obesity during the COVID-19 pandemic.

Web-based high-intensity bodyweight interval training improves metabolic health and physical fitness outcomes in middle-aged men with obesity during the COVID-19 pandemic.

Publication date: Sep 23, 2025

Reduced opportunities for physical activity during the COVID-19 pandemic have heightened obesity-related health risks, emphasizing the need for effective, scalable, and remotely deliverable exercise interventions. This randomized controlled trial examined the efficacy of an 8-week, real-time, supervised, web-based high-intensity interval training (HIIT) program in improving metabolic health and physical fitness in middle-aged men with obesity. Twenty-two men (age 30 kg/m; waist circumference >90 cm) were assigned to a videoconference-based HIIT intervention or a non-exercise control group. The HIIT group completed two supervised sessions per week, each consisting of a standardized warm-up, a 20-min HIIT protocol, and a cool-down, with real-time monitoring and weekly dietary log reviews. Web-based HIIT significantly reduced fat mass by 6. 6% (-2. 01 kg; d = 1. 38) without altering total body weight and improved lipid profiles by increasing HDL cholesterol and decreasing total and LDL cholesterol. Leptin levels decreased, adiponectin increased, and IL-10 rose, whereas IL-6 remained unchanged. Cardiorespiratory fitness improved, with VOmax increasing by 3. 06 mL.kg.min (∼8. 7%) and minute ventilation increasing, and muscle performance was enhanced, as trunk extensor peak torque and average power increased by 9. 7% and 30. 2%, respectively, and knee flexor peak torque increased by 31. 8% (right) and 19. 5% (left), yielding large effect sizes (d = 0. 9-1. 3). These findings indicate that real-time, non-face-to-face HIIT effectively enhances body composition, lipid metabolism, inflammatory balance, aerobic capacity, and functional muscle performance in men with obesity, supporting this contactless modality as a feasible and deployable strategy for health maintenance during and beyond pandemic-related restrictions.

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Concepts Keywords
Cardiorespiratory COVID-19
Dietary metabolic health
Fitness obesity
Obesity web-based exercise intervention
Weekly

Semantics

Type Source Name
disease MESH obesity
disease MESH COVID-19 pandemic
disease MESH body weight
drug DRUGBANK Leptin
drug DRUGBANK Interleukin-10
disease MESH face
drug DRUGBANK Isoxaflutole
pathway REACTOME Reproduction
disease MESH inflammation
disease MESH hypertension
disease MESH cardiovascular disease
disease MESH abdominal obesity
disease MESH insulin resistance
pathway KEGG Insulin resistance
pathway REACTOME Metabolism
disease MESH BMD
drug DRUGBANK Oxygen
disease MESH overnutrition
drug DRUGBANK Dextrose unspecified form
disease MESH included
drug DRUGBANK Ramipril
drug DRUGBANK Methylphenidate
drug DRUGBANK Cholesterol
disease MESH IBM
disease MESH FAP
disease MESH weight gain
disease MESH infectious diseases
disease MESH weight loss
disease MESH dyslipidemia
disease MESH atherosclerosis
disease MESH cytokine storms
disease MESH overweight
drug DRUGBANK Angiotensin II
disease MESH anxiety
disease MESH muscle atrophy
disease MESH bed
drug DRUGBANK Hydrocortisone
drug DRUGBANK Coenzyme M
disease MESH metabolic syndrome
pathway REACTOME Immune System
disease MESH LPS
disease MESH non alcoholic fatty liver disease
disease MESH breast cancer
pathway KEGG Breast cancer
disease MESH death
disease MESH Influenza
drug DRUGBANK Tolbutamide
disease MESH Dis
disease MESH Park
disease MESH Gan

Original Article

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