Publication date: Apr 16, 2026
In a previous cross-sectional study using the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus), deficits in delayed memory, attention, and executive functioning were identified in working-age patients with post-COVID-19 syndrome (PCS) following infection in 2020 or early 2021. Initial assessment occurred approximately five months after infection. To examine short-term longitudinal trajectories, patients were reassessed several months later. Eighty-one patients with PCS (mean age 46. 6 years, 64% female) completed OCS-Plus assessments at baseline and after a median follow-up of 4. 4 months. Cognitive change was analysed using Wilcoxon signed-rank tests and equivalence testing (+/- 1 SD of reference scores) to assess clinical relevance. Associations between cognitive change and changes in depression and fatigue were examined using bootstrap-corrected multiple regression. No significant change in cognitive performance was observed between baseline and follow-up across any cognitive domain (all p > 0. 3). Equivalence testing indicated that observed differences fell within predefined bounds of clinical insignificance (all p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | cognitive impairments |
| disease | MESH | post-COVID-19 syndrome |
| disease | MESH | PCS |
| disease | MESH | infection |
| disease | MESH | fatigue |
| disease | MESH | COVID 19 |
| disease | MESH | syndrome |