The mediating role of suicidal ideation in the relationship between childhood sexual abuse and suicide attempts among Chinese patients with major depressive disorder.

Publication date: Sep 01, 2026

This study aimed to identify the risk factors for suicide attempts among Chinese patients with major depressive disorder (MDD) and explore the mediating role of suicidal ideation between childhood sexual abuse and suicide attempts. Data were derived from a multi-center investigation conducted in nine hospitals across six provinces of China. Suicide attempt status was assessed using the suicide module of the Mini International Neuropsychiatric Interview (MINI), and childhood maltreatment was evaluated via the Childhood Trauma Questionnaire (CTQ). Multivariable logistic regression was used to identify factors associated with suicide attempts, and path analysis-based mediation models were performed to examine the mediating role of suicidal ideation in the relationship between childhood sexual abuse and suicide attempts. A total of 1084 MDD patients were enrolled, among whom 120 (10. 1%) had a history of suicide attempts. Logistic regression analysis showed that suicidal ideation (OR = 8. 73, P

Semantics

Original Article