Publication date: May 13, 2026
Post-tuberculosis lung disease is a well-recognized sequela of pulmonary tuberculosis (PTB). Extra-pulmonary tuberculosis (EPTB) accounts for a quarter of the global tuberculosis burden; yet pulmonary sequelae in people treated for EPTB are unknown. We performed spirometry at successful treatment completion, and semi-annually thereafter for 1. 5 years, among adults (≥18 years) with drug-sensitive PTB and EPTB recruited from outpatient clinics in India. Adult household contacts without current tuberculosis disease underwent spirometry at enrolment and served as non-tuberculosis controls. Logistic and linear regression was used to measure the association of treated EPTB with ventilatory defects and persistence of impaired lung function during post-treatment follow-up, respectively. We enrolled 775 tuberculosis survivors, 275 (35%) of whom were treated for EPTB, and 502 non-tuberculosis controls. Compared to controls, EPTB was associated with lower z-scores for FEV1 (-0. 37, 95%CI -0. 54 to -0. 20, p
| Concepts | Keywords |
|---|---|
| Annually | Controls |
| Global | Eptb |
| Outpatient | Extra |
| Pulmonary | Lung |
| Non | |
| Post | |
| Ptb | |
| Pulmonary | |
| Recognized | |
| Sequela | |
| Spirometry | |
| Treated | |
| Treatment | |
| Tuberculosis | |
| Years |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | Lung Disease |
| disease | MESH | Extra-Pulmonary Tuberculosis |
| disease | MESH | pulmonary tuberculosis |