Publication date: Jul 07, 2026
The aim of this study was to examine changes in serum concentrations of total homocysteine (tHcy), folate, and vitamin B₁₂ (vit B₁₂) in levodopa-nacEFve patients with Parkinson’s disease and mild cognitive impairment (PD-MCI) and to evaluate their association with cognitive function. A retrospective analysis was conducted in 192 levodopa-nacEFve patients with early idiopathic Parkinson’s disease (PD). On the basis of Montreal Cognitive Assessment (MoCA) scores, participants were classified into a PD-MCI group (n = 89) and a Parkinson’s disease with normal cognitive function (PD-NCI) group (n = 103). In addition, 89 healthy individuals who underwent physical examination during the same period were included as a control group. Serum levels of tHcy, folate, and vit B₁₂, as well as cognitive function scores, were compared among the three groups. Compared with the PD-NCI group, patients in the PD-MCI group demonstrated significantly lower scores in visuospatial and executive function, attention and calculation, abstraction, and delayed recall (p
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Folic Acid |
| drug | DRUGBANK | Levodopa |
| disease | MESH | Parkinson’s disease |
| disease | MESH | mild cognitive impairment |
| disease | MESH | included |