Publication date: Jul 08, 2026
Biological aging may contribute to the pathogenesis of major depressive disorder (MDD). However, whether and how peripheral transcriptomic aging increases the risk of MDD onset remains unclear. Transcriptomic age was estimated using peripheral blood RNA sequencing data from 141 individuals with MDD and 134 healthy controls. The residuals of transcriptomic age regressed on chronological age were calculated to indicate transcriptomic aging acceleration. Enrichment analysis was performed to explore potential biological mechanisms underlying aging- and MDD-associated transcriptomic alterations. Associations between transcriptomic aging and clinical, neurocognitive, environmental, genetic, and neuroimaging phenotypes were examined. Participants with MDD exhibited significantly accelerated transcriptomic aging both before (t = 2. 06, P = 0. 040) and after adjusting for chronological age and sex (t = 3. 72, P
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | major depressive disorder |