Publication date: Jul 16, 2026
Fibromyalgia (FM) is a chronic nociplastic pain syndrome characterized by widespread pain, fatigue, and sensory amplification. While FM is linked to increased perioperative resource use and poorer patient-reported outcomes, its influence on in-hospital complications after total hip arthroplasty (THA) remains unclear. We analyzed the National Inpatient Sample (2016-2022) for adults undergoing elective primary THA for osteoarthritis. FM was defined as ICD-10-CM code M79. 7. Exclusions included fracture, revision arthroplasty, infection, malignancy, inflammatory arthritis, COVID-19, and non-elective admissions. A 1:1 nearest-neighbor propensity score match without replacement (caliper 0. 2 SD of logit) balanced demographics, comorbidities, and hospital characteristics. Primary outcomes were length of stay (LOS), total hospital charges, and routine discharge. Secondary outcomes included acute kidney injury (AKI), venous thromboembolism (VTE), pneumonia, postoperative pain, blood-loss anemia, transfusion, intraoperative fracture, and dislocation. From 1,957,284 THA patients, 40,825 (2. 1%) had FM. Post-match (n = 81,650), groups were well balanced (all standardized differences
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| Concepts | Keywords |
|---|---|
| Fibromyalgia | |
| NIS | |
| Post-operative complications | |
| Total hip arthroplasty |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | fibromyalgia |
| disease | MESH | nociplastic pain |
| disease | MESH | syndrome |
| disease | MESH | pain |
| disease | MESH | fatigue |
| drug | DRUGBANK | Tacrine |
| disease | MESH | osteoarthritis |
| disease | MESH | ICD |
| disease | MESH | included |
| disease | MESH | infection |
| disease | MESH | malignancy |
| disease | MESH | arthritis |
| disease | MESH | COVID-19 |
| disease | MESH | acute kidney injury |
| disease | MESH | venous thromboembolism |
| disease | MESH | pneumonia |
| disease | MESH | postoperative pain |
| disease | MESH | anemia |
| disease | MESH | David |
| pathway | REACTOME | Reproduction |
| disease | MESH | fracture dislocation |