Publication date: Jul 18, 2026
Melioidosis, caused by the gram-negative bacillus Burkholderia pseudomallei – a Tier 1 Select Biological agent – remains a significant cause of severe community-acquired infection in tropical regions, but with recent expanding recognition in temperate climates, including the United States. Pulmonary involvement is the most frequent clinical manifestation, ranging from subclinical nodules to fulminant necrotizing pneumonia and acute respiratory distress syndrome. Despite its clinical severity, melioidosis remains underdiagnosed due to its radiologic mimicry of tuberculosis, broad clinical manifestations, and limited laboratory capacity in many endemic areas. Special Operations Forces (SOF) participating in field exercises or operations in B. pseudomallei endemic countries are at significantly increased risk of infection. Accordingly, SOF medical providers should maintain a high index of suspicion for melioidosis and be familiar with its clinical recognition, diagnosis, and management.
| Concepts | Keywords |
|---|---|
| bioagent | |
| biodefense | |
| bioterrorism | |
| Burkholderia pseudomallei | |
| endemic regions | |
| melioidosis | |
| underdiagnosed |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Melioidosis |
| disease | MESH | community-acquired infection |
| disease | MESH | necrotizing pneumonia |
| disease | MESH | acute respiratory distress syndrome |
| disease | MESH | tuberculosis |
| pathway | KEGG | Tuberculosis |
| disease | MESH | infection |