Publication date: Oct 01, 2026
Anti-tuberculosis drug-induced hepatotoxicity (ATDH) remains a significant clinical challenge, highlighting the critical demand for predictive biomarkers. This study aimed to investigate serum zinc protoporphyrin (ZnPP) and protoporphyrin IX (PPIX) as potential ATDH predictors. Blood samples were collected at baseline and two subsequent liver function tests in 58 cases and 191 controls from four hospitals. The ZnPP levels of controls at baseline and two subsequent time points (147. 9, 152. 0 and 147. 5 pg/ml, respectively) were significantly higher than cases (113. 1, 134. 3 and 119. 0 pg/ml), while the PPIX levels were significantly higher in ATDH cases (8. 6, 9. 4 and 9. 1 ng/ml, respectively) than controls (7. 0, 7. 6 and 7. 1 ng/ml) (P
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Protoporphyrin |
| disease | MESH | Chemical and Drug Induced Liver Injury |