Missed Opportunities for Neoadjuvant Immunotherapy in Melanoma: Is it Time to Consider Ultrasound Staging for Newly Diagnosed Patients?

Missed Opportunities for Neoadjuvant Immunotherapy in Melanoma: Is it Time to Consider Ultrasound Staging for Newly Diagnosed Patients?

Publication date: Aug 11, 2026

Melanoma treatment for patients with clinical adenopathy has improved outcomes with neoadjuvant immunotherapy (NAI). Some sentinel lymph node (SLN)-positive patients have larger pathologic metastases that might be identified on ultrasound (US) preoperatively. We sought to identify SLN-eligible patients with larger nodal metastases and identify characteristics to estimate patients who might have nodal metastases identified by staging US. Patients with clinical stage IB/II melanoma who underwent a SLNB for which the pathological size of the metastases were retrospectively identified. Comparative statistics were performed for patients with macrometastases (≥ 10 mm) compared with micrometastases (

Concepts Keywords
10mm Clinical
Adenopathy Diagnosed
Pathological Identified
Stage Identify
Statistics Immunotherapy
Larger
Melanoma
Metastases
Missed
Neoadjuvant
Nodal
Patients
Sln
Staging
Ultrasound

Semantics

Type Source Name
disease MESH Melanoma
pathway KEGG Melanoma
disease MESH adenopathy
disease MESH metastases
disease MESH micrometastases

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