Search Results for: Adenosine

September 16, 2024September 16, 2024

Integrated multiomics revealed adenosine signaling predict immunotherapy response and regulate tumor ecosystem of melanoma.

Melanoma Literature

Publication date: Sep 15, 2024 Extracellular adenosine is extensively involved in regulating the tumor microenvironment. Given the disappointing results of adenosine-targeted therapy trials, personalized treatment might be necessary, tailored to ... Read more

September 11, 2024September 11, 2024

Prolonged intermittent theta burst stimulation restores the balance between A2AR- and A1R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jul 01, 2025 JOURNAL/nrgr/04. 03/01300535-202507000-00027/figure1/v/2024-09-09T124005Z/r/image-tiff An imbalance in adenosine-mediated signaling, particularly the increased A2AR-mediated signaling, plays a role in the pathogenesis of Parkinson’s disease. Existing therapeutic approaches fail ... Read more

August 28, 2024August 28, 2024

Validation of a diagnostic flowchart for tuberculous pleurisy in pleural fluid with high levels of adenosine deaminase.

Tuberculosis Literature

Publication date: Aug 25, 2024 Adenosine deaminase (ADA) in pleural fluid is a useful marker for diagnosing tuberculous pleurisy. However, recent studies have reported a lower specificity of pleural fluid ... Read more

August 28, 2024August 28, 2024

Validation of a diagnostic flowchart for tuberculous pleurisy in pleural fluid with high levels of adenosine deaminase.

Tuberculosis Literature

August 9, 2024August 9, 2024

Adenosine A2AR in viral immune evasion and therapy: unveiling new avenues for treating COVID-19 and AIDS.

Coronavirus Literature

Publication date: Aug 08, 2024 Adenosine is a neuro- and immunomodulator that functions via G protein-coupled cell surface receptors. Several microbes, including viruses, use the adenosine signaling pathway to escape ... Read more

July 29, 2024July 29, 2024

Assessment of ATP metabolism to adenosine by ecto-nucleotidases carried by tumor-derived small extracellular vesicles.

Melanoma Literature

Publication date: Jul 27, 2024 Immunosuppression is a hallmark of cancer progression. Tumor-derived small extracellular vesicles (sEV), also known as TEX, produce adenosine (ADO) and can mediate tumor-induced immunosuppression. Here, ... Read more

July 16, 2024July 16, 2024

Novel immunomodulatory properties of adenosine analogs promote their antiviral activity against SARS-CoV-2.

Coronavirus Literature

Publication date: Jul 15, 2024 The COVID-19 pandemic reminded us of the urgent need for new antivirals to control emerging infectious diseases and potential future pandemics. Immunotherapy has revolutionized oncology ... Read more

October 13, 2024October 13, 2024

“Using the right tools and addressing the right issue”: A qualitative exploration to support better care for intimate partner violence, brain injury, and mental health.

Coronavirus Literature

Publication date: Oct 11, 2024 Intimate partner violence (IPV) is a global public health crisis. Often repetitive and occurring over prolonged periods of time, IPV puts survivors at high risk ... Read more

October 12, 2024October 13, 2024

“Using the right tools and addressing the right issue”: A qualitative exploration to support better care for intimate partner violence, brain injury, and mental health.

Coronavirus Literature

October 12, 2024October 12, 2024

Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis.

Coronavirus Literature

Publication date: Nov 01, 2024 One of the fundamental mechanisms developed by the host to contain the highly infectious and rapidly proliferating SARS-coronavirus is elevation of body temperature, a natural ... Read more