Search Results for: Amyloid

December 7, 2019

Ubiquitination can change the structure of the α-synuclein amyloid fiber in a site selective fashion.

Publication date: Dec 06, 2019 The formation of toxic amyloid aggregates is a common feature of many neurodegenerative diseases. An ever increasing number of biochemical and structural studies have demonstrated ... Read more

December 4, 2019December 4, 2019

Lipid Dynamics and Phase Transition within a-Synuclein Amyloid Fibrils.

Parkinson's Disease Literature

Publication date: Dec 02, 2019 The deposition of co-assemblies made of the small pre-synaptic protein, ?-synuclein, and lipids in the brains of patients is the hallmark of Parkinson’s disease. In ... Read more

September 19, 2019September 19, 2019

Autophagy Modulation as a Treatment of Amyloid Diseases.

Huntington's Disease Literature

Publication date: Sep 16, 2019 Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous amyloid proteins ... Read more

August 1, 2019August 1, 2019

Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation.

Huntington's Disease Literature

Publication date: Aug 01, 2019 Protein and peptides are converted from their soluble forms into highly ordered fibrillar aggregates under various conditions inside the cell. Such transitions confer diverse neurodegenerative ... Read more

June 28, 2019June 28, 2019

The Who, When, Why, and How of PET Amyloid Imaging in Management of Alzheimer’s Disease-Review of Literature and Interesting Images.

Precision Medicine Literature

Publication date: Jun 25, 2019 Amyloid imaging using positron emission tomography (PET) has an emerging role in the management of Alzheimer’s disease (AD). The basis of this imaging is grounded ... Read more

December 17, 2018December 17, 2018

A new frontier for amyloid PET imaging: multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Dec 15, 2018 Morbelli, S., Bauckneht, M., Capitanio, S., Pardini, M., Roccatagliata, L., and Nobili, F. A new frontier for amyloid PET imaging: multiple sclerosis. 16975. 2018 Eur ... Read more

December 5, 2018December 5, 2018

Amyloid-like behavior of site-specifically citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicity.

Multiple Sclerosis Literature

Publication date: Dec 04, 2018 Multiple Sclerosis (MS) is an autoimmune disorder manifested via chronic inflammation, demyelination and neurodegeneration inside the central nervous system (CNS). The progressive phase of MS ... Read more

October 30, 2018October 30, 2018

Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.

Huntington's Disease Literature

Publication date: Oct 26, 2018 The polyglutamine (polyQ) diseases, such as Huntington’s disease and the spinocerebellar ataxias, are characterized by the accumulation of elongated polyQ sequences (epolyQ) and mostly occur ... Read more

October 6, 2018October 6, 2018

Interplay between α-synuclein amyloid formation and membrane structure.

Huntington's Disease Literature

Publication date: Oct 01, 2018 Amyloid formation is a pathological hallmark of many neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. While it is unknown how these disorders are initiated, in ... Read more

September 27, 2018September 27, 2018

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.

Multiple Sclerosis Literature

Publication date: Sep 24, 2018 The α7 nicotinic acetylcholine receptor (α7nAChR) is central to the anti-inflammatory function of the vagus nerve in a physiological mechanism termed the inflammatory reflex. Studies ... Read more