Search Results for: Axonal Growth

July 21, 2019

Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins.

Publication date: Jul 16, 2019 Parkinson’s disease (PD) is a neurodegenerative disease associated with loss or dysfunction of dopaminergic neurons located in the substantia nigra (SN), and there is no ... Read more

March 1, 2019March 1, 2019

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation.

Multiple Sclerosis Literature

Publication date: Feb 27, 2019 The development of neuroprotective therapies is a sought-after goal. By screening combinatorial chemical libraries using in vitro assays, we identified the small molecule BN201 that ... Read more

February 8, 2019February 8, 2019

Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.

Huntington's Disease Literature

Publication date: Feb 06, 2019 High levels of oxidative stress is detected in neurons affected by many neurodegenerative diseases, including huntington’s disease. Many of these diseases also show neuronal cell ... Read more

February 8, 2019February 8, 2019

Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.

Huntington's Disease Literature

July 10, 2019July 10, 2019

Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington’s Disease

Huntington's Disease News

Publication date: Jul 09, 2019 Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have ... Read more

March 28, 2019March 28, 2019

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.

Multiple Sclerosis Literature

Publication date: Mar 27, 2019 Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed, homologous phosphoproteins best known for coordinating cytoskeletal formation and regulating cellular division, migration, polarity, ... Read more

August 11, 2018August 11, 2018

Cerebrospinal fluid GAP-43 in early multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Jan 21, 2018 Novel biomarkers identifying and predicting disease activity in multiple sclerosis (MS) would be valuable for primary diagnosis and as outcome measures for monitoring therapeutic effects ... Read more

February 21, 2018February 21, 2018

Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation.

Multiple Sclerosis Literature

Publication date: Feb 17, 2018 Although inflammation in the central nervous system is responsible for multiple neurological diseases, the lack of appropriate biomarkers makes it difficult to evaluate inflammatory activities ... Read more

June 15, 2019June 15, 2019

Novartis Might Be Holding The Most Promising Neurodegeneration Drug In Development

Huntington's Disease News

Publication date: Jun 15, 2019 Nilotinib, a tyrosine kinase inhibitor developed by Novartis (NYSE:NVS) and approved for leukemia treatment as Tasigna, is being tested in a phase-2 trial for treating ... Read more

June 13, 2019June 13, 2019

Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis.

Multiple Sclerosis Literature

Publication date: Jun 11, 2019 Atrophy has become a clinically relevant marker of progressive neurodegeneration in multiple sclerosis (MS). To better understand atrophy, mouse models that feature atrophy along with ... Read more