Search Results for: Basal ganglia

August 9, 2019August 9, 2019

Dementia associated with disorders of the basal ganglia.

Publication date: Aug 07, 2019 Dementia is now the leading cause of death in the United Kingdom, accounting for over 12% of all deaths and is the fifth most common ... Read more

December 7, 2019December 7, 2019

Single Bout Exercise on Learning in PD

Parkinson's Disease News

Publication date: Dec 06, 2019 Parkinson’s disease (PD) is a neurodegenerative disorder associated with a loss of dopamine in the basal ganglia and is characterized by several cardinal motor signs. ... Read more

December 7, 2019December 7, 2019

Structural Plasticity of GABAergic and Glutamatergic Networks in the Motor Thalamus of Parkinsonian Monkeys.

Parkinson's Disease Literature

Publication date: Dec 06, 2019 In the primate thalamus, the parvocellular ventral anterior nucleus (VApc) and the centromedian nucleus (CM) receive GABAergic projections from the internal globus pallidus (GPi) and ... Read more

December 6, 2019December 6, 2019

Changes in thalamic dopamine innervation in a progressive Parkinson’s disease model in monkeys.

Parkinson's Disease Literature

Publication date: Dec 04, 2019 Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations in PD. The primate thalamus is densely and heterogeneously ... Read more

December 6, 2019December 6, 2019

Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals.

Parkinson's Disease Literature

Publication date: Mar 22, 2019 The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an ... Read more

December 6, 2019December 6, 2019

Impaired dopamine metabolism in Parkinson’s disease pathogenesis.

Parkinson's Disease Literature

Publication date: Aug 20, 2019 A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A ... Read more

December 5, 2019December 5, 2019

Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson’s Disease

Parkinson's Disease News

Publication date: Dec 04, 2019 The objective of this study is to further the understanding and application of 60Hz subthalamic deep brain stimulation (STN-DBS) in Parkinson’s patients with gait disorder. ... Read more

December 4, 2019December 4, 2019

Implicit learning impairment identified via predictive saccades in Huntington’s disease correlates with extended cortico-striatal atrophy.

Huntington's Disease Literature

Publication date: Dec 01, 2019 The ability to anticipate events and execute motor commands prior to a sensory event is an essential capability for human’s everyday life. This implicitly learned ... Read more

December 4, 2019

Pharmacokinetic evaluation of [F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain.

Parkinson's Disease Literature

Publication date: Dec 01, 2019 Dopamine transporters (DAT) modulate pre-synaptic dopamine and physiological functions such as movement and reward. DAT also mirrors disease state in neurological disorders, rendering it an ... Read more

November 27, 2019November 27, 2019

How Can We Apply Guidelines in the Rapidly Changing MS Treatment Landscape?

Multiple Sclerosis Media

Publication date: Nov 26, 2019 Management of multiple sclerosis (MS) occurs in a rapidly changing environment in which decisions must be made using the latest available data and insights. This ... Read more