Search Results for: Blood

March 20, 2019March 20, 2019

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro.

Publication date: Mar 15, 2019 Blood-brain barrier (BBB) disruption is often mediated by neuroinflammation, and occurs during various neurodegenerative diseases including Parkinson’s disease (PD). PD is characterized by loss of ... Read more

March 16, 2019March 16, 2019

Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.

Precision Medicine Literature

Publication date: Mar 14, 2019 Neurological disorders have emerged as a predominant healthcare concern in recent years due to their severe consequences on quality of life and prevalence throughout the ... Read more

March 16, 2019March 16, 2019

Peripheral blood lymphocyte phenotypes in Alzheimer and Parkinson’s diseases.

Parkinson's Disease Literature

Publication date: Mar 11, 2019 Neuroinflammation is involved in the pathophysiology of various neurological disorders, in particular Alzheimer disease (AD) and Parkinson’s disease (PD). Alterations in the blood-brain barrier may ... Read more

March 16, 2019March 16, 2019

DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood.

Parkinson's Disease Literature

Publication date: Mar 14, 2019 Parkinson’s Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms. Unfortunately, patients exhibiting these symptoms have already ... Read more

March 15, 2019March 15, 2019

Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements.

Parkinson's Disease Literature

Publication date: Mar 13, 2019 Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene ... Read more

March 8, 2019March 8, 2019

Generality of Genomic Findings on Blood Pressure Traits and Its Usefulness in Precision Medicine in Diverse Populations: A Systematic Review.

Precision Medicine Literature

Publication date: Feb 28, 2019 Remarkable findings from genome wide association studies (GWAS) on blood pressure (BP) traits have made new insights for developing precision medicine towards more effective screening ... Read more

March 7, 2019March 7, 2019

Increased level of fibrinogen chains in the proteome of blood platelets in secondary progressive multiple sclerosis patients.

Multiple Sclerosis Literature

Publication date: Mar 05, 2019 Epidemiological studies indicate a high risk of stroke, heart failure and myocardial infarction in patients with multiple sclerosis, especially in its secondary progressive (SPMS) phase. ... Read more

February 26, 2019February 26, 2019

Podocalyxin Helps Protect Blood-brain Barrier During Inflammation, Mouse Study Shows

Multiple Sclerosis News

Publication date: Feb 25, 2019 Podocalyxin, a protein found in cells lining the interior of blood vessels, is key for maintaining the integrity of the blood-brain barrier (BBB) in mice ... Read more

February 19, 2019February 19, 2019

Microencapsulated Immunoassays for Detection of Cytokines in Human Blood.

Tuberculosis Literature

Publication date: Feb 18, 2019 Cytokines are produced by leukocytes in blood and may be used as indicators of malignancies or infections. The objective of this study was to develop ... Read more

February 19, 2019February 19, 2019

Effect of dosage reduction on peripheral blood lymphocyte count in patients with multiple sclerosis receiving long-term fingolimod therapy.

Multiple Sclerosis Literature

Publication date: Feb 13, 2019 Of the 19 cases of fingolimod-associated progressive multifocal leukoencephalopathy (PML) reported worldwide by the end of 2017, 4 cases were from Japan. This may indicate ... Read more