Search Results for: Coenzyme M

$Development of a recursive partitioning analysis for prediction of radiation necrosis following single-fraction stereotactic radiosurgery for intact brain metastases.$

May 15, 2025

Development of a recursive partitioning analysis for prediction of radiation necrosis following single-fraction stereotactic radiosurgery for intact brain metastases.

Melanoma Literature

Publication date: May 13, 2025 Radiation necrosis (RN) is a potential complication after stereotactic radiosurgery (SRS) for brain metastases. This study develops a recursive partitioning analysis (RPA) to identify patients ... Read more

May 15, 2025

Interferon-γ orchestrates leptomeningeal anti-tumour response.

Melanoma Literature

Publication date: May 14, 2025 Metastasis to the cerebrospinal-fluid-filled leptomeninges, or leptomeningeal metastasis, represents a fatal complication of solid tumours. Multimodal analyses of clinical specimens reveal substantial inflammatory infiltrate in ... Read more

May 15, 2025

The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment.

Parkinson's Disease Literature

Publication date: May 13, 2025 Imaging genetics is one of the important keys to precision medicine that leads to personalized treatment based on a patient’s genetics, phenotype, or psychosocial characteristics. ... Read more

May 15, 2025

Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: May 14, 2025 Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (aSyn) accumulation. Environmental factors play a significant role in PD progression, ... Read more

May 15, 2025

Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single-center open-label clinical phase I trial (NEON trial).

Parkinson's Disease Literature

Publication date: May 13, 2025 Parkinson disease (PD) is a chronic progressive neurodegenerative disorder leading to motor and non-motor impairment, often resulting in severe loss of quality of life. There ... Read more

May 15, 2025

Helicobacter pylori infection might be a protective factor against Parkinson’s disease.

Parkinson's Disease Literature

Publication date: May 14, 2025 The gastrointestinal tract is not only an important component of the digestive system but also a crucial part of the body’s immune system. Numerous studies ... Read more

May 15, 2025

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair.

Huntington's Disease Literature

Publication date: May 14, 2025 FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His ... Read more

May 15, 2025

Visualization of autophagic structures near solid polyQ aggregates reveals how they undermine autophagy.

Huntington's Disease Literature

Publication date: May 14, 2025 Aggregates of polyglutamine (polyQ) repeat extensions are known markers of several, predominantly inherited, neurodegenerative diseases. Removal of polyQ is essential for cellular proteostasis and macroautophagy/autophagy ... Read more

May 15, 2025May 15, 2025

A FAN1 point mutation associated with accelerated Huntington’s disease progression alters its PCNA-mediated assembly on DNA.

Huntington's Disease Literature

Publication date: May 14, 2025 FAN1 is an endo- and exo-nuclease involved in DNA and interstrand crosslink repair. Genome-wide association studies of people with Huntington’s disease revealed a strong association ... Read more

May 15, 2025

Effects of Ninjin’yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats.

Major Depressive Disorder Literature

Publication date: May 13, 2025 Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans and animals, rendering it a novel therapeutic option for post-stroke depression ... Read more